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<div class=Section1>
<h1 style='margin:0in;margin-bottom:.0001pt'><span style='font-family:Times;
mso-bidi-font-family:"Courier New"'>Broad Institute Public License 1.0<o:p></o:p></span></h1>
<h1 style='margin:0in;margin-bottom:.0001pt'><span style='font-family:Times;
mso-bidi-font-family:"Courier New"'>(BIPL 1.0)<o:p></o:p></span></h1>
<h1 style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New";font-weight:normal;
mso-bidi-font-weight:bold'><o:p> </o:p></span></h1>
<p style='margin:0in;margin-bottom:.0001pt'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>1. DEFINITIONS.<o:p></o:p></span></b></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><span
style='mso-spacerun:yes'> </span><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>1.1. “Commercial Use</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”<span style='mso-bidi-font-weight:
bold'> </span></span></b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>means distribution or otherwise making the
Covered Code available to a third party.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.2. “Contributor</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means each individual
that creates or contributes to the creation of Modifications, whether on his or
her own behalf or on behalf of his or her employer.<span
style='mso-spacerun:yes'> </span>“Contributor” shall not include Initial
Developer, notwithstanding any Modifications that may be contributed by Initial
Developer.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.3. “Covered Code</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means the Original
Code or Modifications or the combination of the Original Code and
Modifications, in each case in their entirety or any portions thereof<b>.<o:p></o:p></b></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></b></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.4. “Effective Date”</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New";
mso-bidi-font-weight:bold'> means the </span><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>date You download the
Covered Code and exercise any of the rights granted to You in this License.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.5. “Electronic Distribution Mechanism</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means a mechanism
generally accepted in the software development community for the electronic
transfer of data or software programs.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.6. “Executable</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means Covered
Code in any form other than Source Code.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.7. “Initial Developer</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means the
individual(s) or entity(ies) identified as the Initial Developer in the Source
Code notice required by <span style='mso-bidi-font-weight:bold'>Exhibit A</span>.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.8. “Larger Work</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means a work
which combines Covered Code with code not governed by the terms of this License
and which is not a Modification.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.9. “License</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means this
document.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.10. “Licensable</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means having the
right to grant, whether at the time of the initial grant or subsequently
acquired, any and all of the rights conveyed herein.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.11. “Modifications</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means: (i) any
addition to or deletion from the substance or structure of the Original Code;
or (ii) any addition or deletion to the results of (i).<span
style='mso-spacerun:yes'> </span>Each of (i) and (ii) and any continuing
additions or deletions to (i) and (ii) are all Modifications. <span
style='mso-spacerun:yes'> </span>When Covered Code is released as a series of
files, a Modification is:<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>(a)</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> Any
addition to or deletion from the contents of a file containing Original Code or
previous Modifications; or <o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>(b)</span></b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'> Any new file that
contains any part of the Original Code or previous Modifications. <br
style='mso-special-character:line-break'>
<![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'>
<![endif]><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>1.12. “Original Code</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means Source Code
of computer software code described as “Original Code” in the Source Code
notice required by <span style='mso-bidi-font-weight:bold'>Exhibit A</span>.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.13. “Patent Claims</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means any patent
claim(s), now owned or hereafter acquired, including without limitation, method,
process, and apparatus claims, in any patent Licensable by Contributor.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.14. “Source Code</span></b><b
style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;font-family:
Times;mso-bidi-font-family:"Courier New"'>”</span></b><span style='font-size:
10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'> means the
preferred form of Covered Code for making modifications to it, including all
modules it contains, plus any associated interface definition files, scripts
used to control compilation and installation of an Executable, or source code
comparisons against either the Original Code or another well known, available
Covered Code of the Contributor's choice. <span
style='mso-spacerun:yes'> </span>The Source Code can be in a compressed or
archival form provided the appropriate decompression or de-archiving software
is widely available for no charge.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>1.15. “You</span></b><b style='mso-bidi-font-weight:
normal'><span style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:
"Courier New"'>”<span style='mso-bidi-font-weight:bold'> (or “Your</span>”<span
style='mso-bidi-font-weight:bold'>) </span></span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>
means an individual exercising rights under, and complying with all of the
terms of, this License or a future version of this License issued pursuant to Section
5.1.<o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></b></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>2. SOURCE CODE LICENSE.</span></b></tt><tt><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>2.1. The Initial
Developer Grant.</span></b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><br style='mso-special-character:line-break'>
<![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'>
<![endif]><o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>Subject to third party intellectual
property claims, the Initial Developer hereby grants You, as of the Effective Date,
a world-wide, royalty-free, non-exclusive license, under intellectual property
rights (other than patent or trademark) Licensable by Initial Developer, to run,
reproduce, modify, display, perform, sublicense, and distribute the Original
Code (or portions thereof) with or without Modifications, and/or as part of a
Larger Work. <o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'> <o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>2.2. Contributor Grant.</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><br
style='mso-special-character:line-break'>
<![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'>
<![endif]><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>Subject to third party
intellectual property claims, each Contributor hereby grants the Initial
Developer and You, as of the Effective Date, a world-wide, royalty-free,
non-exclusive license:<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'> <br>
<b>(a)</b> under intellectual property rights (other than patent or
trademark) Licensable by Contributor, to run, reproduce, modify, display,
perform, sublicense, and distribute the Modifications created by such Contributor
(or any portions thereof) either on an unmodified basis, with Modifications, as
Covered Code, and/or as part of a Larger Work; and<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>(b)</span></b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'> under Patent Claims Licensable
by Contributor that are infringed by the exercise of the license granted under
Section 2.2(a), and solely to the extent necessary to exercise the license
granted under Section 2.2(a),<span style='color:black'> to make, use, sell,
offer for sale, or import: 1) Modifications made by that Contributor (or any portions
thereof); and 2) the combination of Modifications made by that
Contributor with its version of Covered Code (or any portions of such
combination)</span>. <o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><br>
<b>3. DISTRIBUTION OBLIGATIONS.</b><o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>3.1. Application of
License and Additional Terms.</span></b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><br style='mso-special-character:
line-break'>
<![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'>
<![endif]><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>This License applies to
code to which the Initial Developer has attached the notice in <span
style='mso-bidi-font-weight:bold'>Exhibit A</span> and to resulting Covered
Code.<span style='mso-spacerun:yes'> </span>The Modifications which You create
or to which You contribute are governed by all of the terms of this License. <span
style='mso-spacerun:yes'> </span>The Source Code version of Covered Code shall be
distributed only under the terms of this License or a future version of this
License released in accordance with Section <span style='mso-bidi-font-weight:
bold'>5.1</span>, and You must include a copy of this License with every copy
of the Source Code You distribute. <span style='mso-spacerun:yes'> </span>You
may not offer or impose any terms on any Source Code version that alters or
restricts the applicable version of this License or the recipients' rights
hereunder. <span style='mso-spacerun:yes'> </span>However, You may choose to
offer, and to charge a fee for, warranty, support, indemnity, or liability
obligations to one or more recipients of Covered Code; provided that You do so
only on Your own behalf and not on behalf of the Initial Developer or any
Contributor.<span style='mso-spacerun:yes'> </span>You must make it absolutely
clear than any such warranty, support, indemnity, or liability obligation is
offered by You alone, and You hereby agree to indemnify the Initial Developer
and every Contributor for any liability incurred by the Initial Developer or
such Contributor as a result of warranty, support, indemnity, or liability
terms You offer..<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>3.2. Availability of Source Code.</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><br
style='mso-special-character:line-break'>
<![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'>
<![endif]><o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>Any Modification that You create or to
which You contribute must be made available in Source Code form under the terms
of this License either on the same media as an Executable version or via an
accepted Electronic Distribution Mechanism to anyone to whom You made an Executable
version available; and if made available via Electronic Distribution Mechanism,
must remain available for at least twelve (12) months after the Effective Date,
or at least six (6) months after a subsequent version of that particular
Modification has been made available to such recipients. <span
style='mso-spacerun:yes'> </span>You are responsible for ensuring that the
Source Code version remains available even if the Electronic Distribution
Mechanism is maintained by a third party.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>3.3. Description of Modifications.</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><br
style='mso-special-character:line-break'>
<![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'>
<![endif]><o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>You must cause all Covered Code to which
You contribute to contain a file documenting the changes You made to create
that version of Covered Code and the date of any change. <span
style='mso-spacerun:yes'> </span>You must include a prominent statement that
the Modification is derived, directly or indirectly, from Original Code
provided by the Initial Developer and including the name of the Initial
Developer in (a) the Source Code, and (b) in any notice in an Executable
version or related documentation in which You describe the origin or ownership
of the Covered Code.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>3.4. Intellectual Property Matters.<o:p></o:p></span></b></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>(a) Third Party Claims</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><br>
If Contributor has knowledge that a license under a third party's intellectual
property rights is required to exercise the rights granted by such Contributor
under Section 2.2, Contributor must include a text file with the Source Code
distribution titled <span style='mso-bidi-font-weight:bold'>“</span>LEGAL,<span
style='mso-bidi-font-weight:bold'>”</span> which describes the claim and the
party making the claim in sufficient detail that a recipient will know who to
contact. <span style='mso-spacerun:yes'> </span>If Contributor obtains such
knowledge after Contributor makes the Covered Code available, Contributor shall
promptly modify the LEGAL file in all copies Contributor makes available
thereafter and shall take other steps (such as notifying appropriate mailing
lists or newsgroups) reasonably calculated to inform those who received the
Covered Code from Contributor that new knowledge has been obtained.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>(b) Contributor APIs</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><br>
If Contributor's Modifications include an application programming interface and
Contributor has knowledge of patent licenses which are reasonably necessary to
implement that API, Contributor must also include this information in the LEGAL
file.<br>
<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>(c) Representations.</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>Contributor represents
that, except as disclosed pursuant to Section 3.4(a) above, Contributor
believes that Contributor's Modifications are Contributor's original
creation(s) and/or Contributor has sufficient rights to grant the rights
conveyed by this License.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><br>
<b>3.5. Required Notices.</b><o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><br>
You must duplicate the notice in <span style='mso-bidi-font-weight:bold'>Exhibit
A</span> in each file of the Source Code. If it is not possible to put
such notice in a particular Source Code file due to its structure, then You
must include such notice in a location (such as a relevant directory) where a
user would be likely to look for such a notice. If You created one or
more Modification(s), You shall add Your name as a Contributor to the notice
described in <span style='mso-bidi-font-weight:bold'>Exhibit A</span>.
You must also duplicate this License in any documentation for the Source Code that
You distribute where You describe recipients' rights or ownership rights
relating to the Covered Code.<o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>3.6. Distribution of Executable Versions.</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><br>
You may distribute Covered Code in Executable form only if You have met the
requirements of Section <span style='mso-bidi-font-weight:bold'>3.1-3.5</span>
for that Covered Code, and if You include a notice stating that the Source Code
version of the Covered Code is available under the terms of this License,
including a description of how and where You have fulfilled the obligations of
Section <span style='mso-bidi-font-weight:bold'>3.2</span>. <span
style='mso-spacerun:yes'> </span>The notice must be conspicuously included in
any notice in an Executable version, related documentation, or other related
material in which You describe recipients' rights relating to the Covered Code.
<span style='mso-spacerun:yes'> </span>You may distribute the Executable
version of Covered Code under a license of Your choice, which may contain terms
different from this License, provided that You are in compliance with the terms
of this License and that the license for the Executable version does not
attempt to limit, expand, or alter the recipient's rights in the Source Code
version from the rights set forth in this License. <span
style='mso-spacerun:yes'> </span>If You distribute the Executable version under
a different license, You must make it absolutely clear that any terms which
differ from or are in addition to this License are offered by You alone, not by
the Initial Developer or any Contributor. <span
style='mso-spacerun:yes'> </span>You hereby agree to indemnify the Initial
Developer and every Contributor for any liability incurred by the Initial
Developer or such Contributor as a result of any such terms You offer.<o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>3.7. Larger Works.</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><br>
You may create a Larger Work by combining Covered Code with other code not governed
by the terms of this License and distribute the Larger Work as a single
product. <span style='mso-spacerun:yes'> </span>In such a case, You must make
sure the requirements of this License are fulfilled for the Covered Code.<o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>4. INABILITY TO COMPLY DUE TO STATUTE OR
REGULATION.</span></b></tt><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><b style='mso-bidi-font-weight:
normal'><span style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:
"Courier New"'>4.1. Comply to the Maximum Extent Possible; Provide Notice.<o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>If it is impossible for
You to comply with any of the terms of this License with respect to some or all
of the Covered Code due to statute, judicial order, or regulation then You
must: (a) comply with the terms of this License to the maximum extent possible;
and (b) describe the limitations and the portion of the Covered Code they
affect. <span style='mso-spacerun:yes'> </span>Such description must be
included in the LEGAL file described in Section <span style='mso-bidi-font-weight:
bold'>3.4</span> and must be included with all distributions of the Source
Code. <span style='mso-spacerun:yes'> </span>Except to the extent prohibited by
statute or regulation, such description must be sufficiently detailed for a
recipient of ordinary skill to be able to understand it.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><b style='mso-bidi-font-weight:
normal'><span style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:
"Courier New"'>4.2. Export Controls.<o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>If Your exercise of any
rights granted in this License causes the Initial Developer or any Contributor
to violate any applicable United States laws, regulations, executive orders and
governmental requirements imposing export controls on certain items, materials,
software, and technical information, or imposing embargoes, sanctions and/or
other restrictions on making payments to, providing services or anything of
value to, travel to, contracting with, or taking other actions respecting
sanctioned countries, individuals and entities, or prohibiting corrupt payments
and other practices in dealings with any foreign (non-U.S.) government,
official, other entity or person, including without limitation, the Foreign
Corrupt Practices Act, the Arms Export Control Act, the laws and regulations
administered by the Office of Foreign Assets Control of the U.S. Treasury
Department, by the Bureau of Industry and Security of the Commerce Department,
or by the Directorate of Defense Trade Controls of the State Department (and
their successor agencies), and Executive Order 13224 (collectively, <span
style='mso-bidi-font-weight:bold'>“</span>Restrictions<span style='mso-bidi-font-weight:
bold'>”</span>), then all rights granted to You under this License shall
immediately terminate.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>5. VERSIONS OF THE LICENSE.</span></b></tt><tt><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>5.1. New Versions</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><br>
The Initial Developer may publish revised and/or new versions of the License
from time to time.<span style='mso-spacerun:yes'> </span>Each version will be
given a distinguishing version number.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>5.2. Effect of New Versions</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><br>
Once Covered Code has been published under a particular version of the License,
You may always continue to use it under the terms of that version. <span
style='mso-spacerun:yes'> </span>You may also choose to use such Covered Code
under the terms of any subsequent version of the License published by the
Initial Developer. <span style='mso-spacerun:yes'> </span>No one other than the
Initial Developer has the right to modify the License terms applicable to
Covered Code created under this License.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>5.3. Derivative Licenses</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><br>
If You create or use a modified version of this License (which You may only do
in order to apply it to code which is not already Covered Code governed by this
License), You must (a) rename Your license so that the phrases <span
style='mso-bidi-font-weight:bold'>“</span>Broad,<span style='mso-bidi-font-weight:
bold'>”</span> <span style='mso-bidi-font-weight:bold'>“</span>Broad Institute,<span
style='mso-bidi-font-weight:bold'>”</span> <span style='mso-bidi-font-weight:
bold'>“</span>BIPL,<span style='mso-bidi-font-weight:bold'>”</span> <span
style='mso-bidi-font-weight:bold'>“</span>Massachusetts Institute of
Technology,<span style='mso-bidi-font-weight:bold'>”</span> <span
style='mso-bidi-font-weight:bold'>“</span>MIT,<span style='mso-bidi-font-weight:
bold'>”</span> <span style='mso-bidi-font-weight:bold'>“</span>The Eli and
Edythe L. Broad Institute,<span style='mso-bidi-font-weight:bold'>”</span> <span
style='mso-bidi-font-weight:bold'>“</span>The Eli and Edythe L. Broad
Institute, A Collaboration of Massachusetts Institute of Technology, Harvard
University and affiliated Hospitals, and Whitehead Institute for Biomedical
Research,<span style='mso-bidi-font-weight:bold'>”</span> <span
style='mso-bidi-font-weight:bold'>“</span>Whitehead,<span style='mso-bidi-font-weight:
bold'>”</span> <span style='mso-bidi-font-weight:bold'>“</span>Whitehead
Institute,<span style='mso-bidi-font-weight:bold'>”</span> <span
style='mso-bidi-font-weight:bold'>“</span>WIBR,<span style='mso-bidi-font-weight:
bold'>”</span> or any confusingly similar phrase do not appear in Your license
(except to note that Your license differs from this License) and (b) otherwise
make it clear that Your version of the license contains terms which differ from
the Broad Institute Public License.<span style='mso-spacerun:yes'> </span>(Filling
in the name of the Initial Developer, Original Code, or Contributor in the
notice described in <span style='mso-bidi-font-weight:bold'>Exhibit A</span>
shall not of themselves be deemed to be modifications of this License).<o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>6. DISCLAIMER OF WARRANTY; LIMITATION OF
LIABILITY.</span></b></tt><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>EXCEPT AS PROVIDED IN
SECTION 3.4(c), COVERED CODE IS PROVIDED UNDER THIS LICENSE ON AN AS IS BASIS,
WITHOUT WARRANTY OF ANY KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING, WITHOUT
LIMITATION, WARRANTIES THAT THE COVERED CODE IS FREE OF DEFECTS, MERCHANTABLE,
FIT FOR A PARTICULAR PURPOSE, OR NON-INFRINGING. <span
style='mso-spacerun:yes'> </span>THE ENTIRE RISK AS TO THE QUALITY AND
PERFORMANCE OF THE COVERED CODE IS WITH YOU. <span
style='mso-spacerun:yes'> </span>SHOULD ANY COVERED CODE PROVE DEFECTIVE IN ANY
RESPECT, YOU (NOT THE INITIAL DEVELOPER OR ANY CONTRIBUTOR) ASSUME THE COST OF
ANY NECESSARY SERVICING, REPAIR, OR CORRECTION. <span
style='mso-spacerun:yes'> </span>THIS DISCLAIMER OF WARRANTY CONSTITUTES AN
ESSENTIAL PART OF THIS LICENSE. <span style='mso-spacerun:yes'> </span>NO USE
OF ANY COVERED CODE IS AUTHORIZED HEREUNDER EXCEPT UNDER THIS DISCLAIMER.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>UNDER NO CIRCUMSTANCES
AND UNDER NO LEGAL THEORY, WHETHER TORT (INCLUDING NEGLIGENCE OR STRICT
LIABILITY), CONTRACT, OR OTHERWISE, SHALL YOU, THE INITIAL DEVELOPER, ANY OTHER
CONTRIBUTOR, OR ANY DISTRIBUTOR OF COVERED CODE, OR ANY SUPPLIER TO ANY OF SUCH
PARTIES, BE LIABLE TO ANY PERSON FOR ANY INDIRECT, SPECIAL, INCIDENTAL, OR
CONSEQUENTIAL DAMAGES OF ANY CHARACTER INCLUDING, WITHOUT LIMITATION, DAMAGES
FOR LOSS OF GOODWILL, WORK STOPPAGE, COMPUTER FAILURE OR MALFUNCTION, OR ANY
AND ALL OTHER COMMERCIAL DAMAGES OR LOSSES, EVEN IF SUCH PARTY SHALL HAVE BEEN
INFORMED OF THE POSSIBILITY OF SUCH DAMAGES.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>7. TERMINATION.</span></b></tt><tt><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>7.1. Breach.<o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New";mso-bidi-font-weight:bold'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New";mso-bidi-font-weight:bold'>In
addition to termination under Section 4.2, </span><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>this License and the
rights granted hereunder will terminate automatically if You fail to comply
with terms herein and fail to cure such breach within 30 days of becoming aware
of the breach.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>7.2. Patent Infringement Litigation.<o:p></o:p></span></b></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><b style='mso-bidi-font-weight:normal'><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></b></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><b style='mso-bidi-font-weight:normal'><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>(a)<span
style='mso-spacerun:yes'> </span>Immediate Termination.<o:p></o:p></span></b></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>If You initiate patent infringement litigation
against Initial Developer or a Contributor (the Initial Developer or
Contributor against whom You file such action is referred to as <span
style='mso-bidi-font-weight:bold'>“</span>Participant<span style='mso-bidi-font-weight:
bold'>”</span>) and/or against any entity affiliated with the Participant and/or
that employs the Participant with respect to a patent applicable to Covered
Code, or any portion thereof, then all rights granted to You under Sections 2.1
and 2.2 shall terminate as of the date such litigation is filed.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><b style='mso-bidi-font-weight:normal'><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>(b)<span
style='mso-spacerun:yes'> </span>Value of License.</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:1.0in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>If You assert a patent infringement claim
against Participant and/or any related entity alleging that exercise of the
rights granted in this License <span style='mso-spacerun:yes'> </span>directly
or indirectly infringes any patent where such claim is resolved (such as by
license or settlement) prior to the initiation of or final resolution of patent
infringement litigation, then the reasonable value of the licenses granted to
You under Sections 2.1 and/or 2.2 shall be taken into account in determining
the amount or value of any payment or license.<o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>7.3.</span></b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'> <b>Sublicenses;
Survival.<o:p></o:p></b></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></b></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>In the event of termination under Sections 7.1
or 7.2(a) above, all sublicenses to the Covered Code which are properly
granted under this License, and remain subject to this License, shall survive
any termination of this License.<span style='mso-spacerun:yes'> </span>Provisions
which, by their nature, must remain in effect beyond the termination of this
License shall survive.<span style='mso-spacerun:yes'> </span>In the event of
termination under Section 4.2, compliant sublicenses shall survive solely to
the extent that such sublicenses do not violate the laws and regulations, etc.
described in Section 4.2.<o:p></o:p></span></p>
<p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<pre><b style='mso-bidi-font-weight:normal'><span style='font-family:Times;
mso-bidi-font-family:"Courier New"'>8. TRADEMARKS.<o:p></o:p></span></b></pre><pre
style='margin-left:.5in'><span style='font-family:Times;mso-bidi-font-family:
"Courier New"'><o:p> </o:p></span></pre><pre style='margin-left:.5in'><span
style='font-family:Times;mso-bidi-font-family:"Courier New"'>This License does not grant any rights to use the trademarks, service marks, logos, or trade names belonging to: the Whitehead Institute for Biomedical Research; the Massachusetts Institute of Technology; or the Eli and Edythe L. Broad Institute, A Collaboration of Massachusetts Institute of Technology, Harvard University and affiliated Hospitals, and Whitehead Institute for Biomedical Research; or to any trademark, service mark, logo, or trade name belonging to any Contributor.<o:p></o:p></span></pre>
<p class=MsoNormal><span style='font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>9. <st1:place w:st="on"><st1:country-region
w:st="on">U.S.</st1:country-region></st1:place> GOVERNMENT END USERS.</span></b></tt><tt><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><b style='mso-bidi-font-weight:
normal'><span style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:
"Courier New"'>9.1. Commercial Item.</span></b><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>Except as may be
described in Exhibit A, the Covered Code is a ''commercial item,'' as that term
is defined in 48 C.F.R. 2.101 (Oct. 1995), consisting of ''commercial computer
software'' and ''commercial computer software documentation,'' as such terms
are used in 48 C.F.R. 12.212 (Sept. 1995). <span
style='mso-spacerun:yes'> </span>Consistent with 48 C.F.R. 12.212 and 48 C.F.R.
227.7202-1 through 227.7202-4 (June 1995), all U.S. Government end users acquire
Covered Code with only those rights set forth herein.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><b style='mso-bidi-font-weight:
normal'><span style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:
"Courier New"'>9.2. Obligations to the <st1:place w:st="on"><st1:country-region
w:st="on">United States</st1:country-region></st1:place> Government.</span></b><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>To the extent any
Contributor’s Modification is subject to licensing obligations to the United
States Government, such obligations shall be listed directly under
Contributor’s name on Exhibit A and shall describe the portion of the Modification
to which such obligation applies.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>10. MISCELLANEOUS.</span></b></tt><tt><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>This License represents
the complete agreement concerning subject matter hereof. <span
style='mso-spacerun:yes'> </span>If any provision of this License is held to be
unenforceable, such provision shall be reformed only to the extent necessary to
make it enforceable. <span style='mso-spacerun:yes'> </span>This License shall
be governed by <st1:State w:st="on"><st1:place w:st="on"><st1:City w:st="on">Massachusetts</st1:City></st1:place></st1:State>
law, excluding its conflict-of-law provisions (except that questions affecting
the construction and effect of any patent shall be determined by the law of the
country in which the patent shall have been granted). <span
style='mso-spacerun:yes'> </span>With respect to disputes in which at least one
party is a citizen of, or an entity chartered or registered to do business in
the United States of America, any litigation relating to this License shall be
subject to the jurisdiction of the Federal Courts of Massachusetts, with venue
lying in Suffolk County, Massachusetts, with the losing party responsible for
costs, including without limitation, court costs and reasonable attorneys' fees
and expenses. <span style='mso-spacerun:yes'> </span>The application of the
United Nations Convention on Contracts for the International Sale of Goods is
expressly excluded. <span style='mso-spacerun:yes'> </span>Any law or
regulation which provides that the language of a contract shall be construed
against the drafter shall not apply to this License.<span
style='mso-spacerun:yes'> </span>This License may be translated but the
English version is the official version.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:Times;mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>11. RESPONSIBILITY FOR CLAIMS.</span></b></tt><tt><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>As between and among Initial
Developer and Contributors, each party is responsible, jointly but not
severally, for claims and damages arising, directly or indirectly, out of its grants
and/or exercise of rights under this License, and You agree to cooperate with
Initial Developer and Contributors to distribute such responsibility on an
equitable basis. <span style='mso-spacerun:yes'> </span>Nothing herein is
intended or shall be deemed to constitute any admission of liability.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:
"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal><tt><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>12. MULTIPLE-LICENSED CODE.</span></b></tt><tt><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'><o:p></o:p></span></tt></p>
<p class=MsoNormal><tt><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></tt></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'>Initial Developer may
designate portions of the Covered Code as Multiple-Licensed. Multiple-Licensed
means that the Initial Developer permits You to utilize portions of the Covered
Code under Your choice of the Broad Institute Public License or the alternative
licenses, if any, specified by the Initial Developer in the file described in
Exhibit A.<o:p></o:p></span></p>
<span style='font-size:10.0pt;font-family:Times;mso-fareast-font-family:"Times New Roman";
mso-bidi-font-family:"Courier New";mso-ansi-language:EN-US;mso-fareast-language:
EN-US;mso-bidi-language:AR-SA'><br clear=all style='page-break-before:always'>
</span>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>EXHIBIT A - Broad Institute Public License
(BIPL).<o:p></o:p></span></b></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:
"Courier New"'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New";mso-bidi-font-weight:bold'>“</span><span
style='font-size:10.0pt;font-family:Times;mso-bidi-font-family:"Courier New"'>The
contents of this file are subject to the Broad Institute Public License (the <span
style='mso-bidi-font-weight:bold'>“</span>License<span style='mso-bidi-font-weight:
bold'>”</span>); You may not use this file except in compliance with the
License. <span style='mso-spacerun:yes'> </span>You may obtain a copy of the
License at [INSERT LICENSE DOWNLOAD WEBSITE HERE].<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in'><span style='font-size:10.0pt;
font-family:Times;mso-bidi-font-family:"Courier New"'><span
style='mso-spacerun:yes'> </span><o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>Software distributed under the License is
distributed on an <span style='mso-bidi-font-weight:bold'>“</span>AS IS<span
style='mso-bidi-font-weight:bold'>”</span> basis, WITHOUT WARRANTY OF ANY KIND,
either express or implied. <span style='mso-spacerun:yes'> </span>See the
License for the specific language governing rights and limitations under the
License. <o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>The Original Code is
______________________________________, available at [INSERT ORIGINAL CODE DOWNLOAD
WEBSITE HERE]. <o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>The Initial Developer of the Original Code
is: (i) the Whitehead Institute for Biomedical Research (<span
style='mso-bidi-font-weight:bold'>“</span>WIBR<span style='mso-bidi-font-weight:
bold'>”</span>); and (ii) the Massachusetts Institute of Technology (<span
style='mso-bidi-font-weight:bold'>“</span>MIT<span style='mso-bidi-font-weight:
bold'>”</span>) through the Eli and Edythe L. Broad Institute, A Collaboration
of Massachusetts Institute of Technology, <st1:place w:st="on"><st1:PlaceName
w:st="on">Harvard</st1:PlaceName> <st1:PlaceType w:st="on"><st1:PostalCode
w:st="on">University</st1:PostalCode></st1:PlaceType></st1:place> and
affiliated Hospitals, and Whitehead Institute for Biomedical Research (the <span
style='mso-bidi-font-weight:bold'>“</span>Broad Institute<span
style='mso-bidi-font-weight:bold'>”</span>).<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>Portions created by WIBR are copyright
© Whitehead Institute for Biomedical Research, <u>[YEAR]</u>.<span
style='mso-spacerun:yes'> </span>Portions created by MIT are copyright ©
Massachusetts Institute of Technology (Broad Institute), <u>[YEAR]</u>.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>Contributor(s): ______________________________________.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><span style='mso-tab-count:1'> </span>Government
Rights, if any: _______________________________.<o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>Alternatively, the contents of this Contributor’s
file may be used under the terms of the _____ license (the [___] License), in
which case the provisions of [______] License are applicable instead of
those above. If You wish to allow use of Your version of this file only
under the terms of the [____] License and not to allow others to use Your
version of this file under the BIPL, indicate Your decision by
deleting the provisions above and replace them with the notice and
other provisions required by the [___] License. If You do not delete the
provisions above, a recipient may use Your version of this file under either
the BIPL or the [___] License.<span style='mso-bidi-font-weight:bold'>”</span> <o:p></o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'><o:p> </o:p></span></p>
<p style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:.5in;
margin-bottom:.0001pt'><span style='font-size:10.0pt;font-family:Times;
mso-bidi-font-family:"Courier New"'>[NOTE: The text of this Exhibit A may
differ slightly from the text of the notices in the Source Code files of the
Original Code. <span style='mso-spacerun:yes'> </span>You should use the text
of this Exhibit A rather than the text found in the Original Code Source Code
for Your Modifications.] <o:p></o:p></span></p>
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